Biological functions of migrasome defined by the cargo specificity

报告题目：Biological functions of migrasome defined by the cargo specificity

报告人简介：焦海峰，复旦大学基础医学院研究员、博士生导师，复旦大学附属肿瘤医院双聘教授。2020年毕业于清华大学获博士学位，2025年全职加入复旦大学医学院。致力于迁移体生物学的研究，从分子机制、细胞功能及生理意义三个维度，系统阐释了迁移体发挥生物学功能的机制与模式。发现并命名了一种全新的线粒体质量控制机制——线粒体胞吐，建立了迁移体维持细胞稳态的功能模式；揭示了迁移体整合信号分子并定点释放机制，建立了迁移体介导细胞间通讯的功能模式。这些工作不仅系统地推动了迁移体生物学的发展，也为线粒体质量控制、细胞分泌、细胞间通讯与炎症反应等领域带来了创新与进步。申请人以第一作者或共同通讯作者在Cell、Cell Research、Journal of Cell Biology等期刊发表系列高水平论文多篇。

报告简介：Migrasomes are recently identified extracellular organelles that form on retraction fibers. They are widely involved in various physiological and pathological processes and exhibit high functional diversity. The cargo within migrasomes serves as the foundation for their biological functions. Migrasomes carry a wide array of cargo, including but not limited to secretory proteins, damaged organelles, nucleic acids, viral particles, and coagulation factors. Emerging evidence indicates that this cargo is actively loaded into migrasomes via specific mechanisms, while its release is governed by distinct regulatory pathways. In this talk, I will discuss the principles behind the selective sorting, transport, and release of cargo within migrasomes, with a particular emphasis on what cargo can be encapsulated; how this cargo is selectively sorted and transported into migrasomes; and the roles that migrasomes can play depending on this cargo.

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